Selank 10mg

Selank 10mg: Advanced Neurobiological Research Peptide

Selank is a synthetic heptapeptide and a potent analogue of the naturally occurring tetrapeptide Tuftsin. Originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has become a primary subject of interest in the fields of neurobiology and psychopharmacology.

Our 10mg lyophilized vial of Selank is produced to the highest specifications, ensuring a purity level of $\ge 99\%$. This research-grade compound is designed for scientists investigating the modulation of the central nervous system and the biochemical pathways of the stress response.

Chemical Profile and Structural Specifications

Selank is a modified version of Tuftsin, with a C-terminal pro-gly-pro (PGP) sequence added to enhance its stability and metabolic half-life in laboratory environments.

• Molecular Formula: $C_{33}H_{57}N_{11}O_{9}$

• Molecular Weight: $751.9 \text{ g/mol}$

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro

• CAS Number: 129954-34-3

• Purity: $\ge 99\%$ (HPLC/MS verified)

• Physical State: Sterile, white, lyophilized powder

Mechanism of Action: Neuro-Modulation and GABAergic Influence

Selank operates through several complex pathways within the brain, distinguishing it from traditional pharmacological agents. Its research value lies in its ability to influence the nervous system without the typical sedative effects associated with benzodiazepines.

1. GABAergic System Modulation

Research indicates that Selank may modulate the activity of the neurotransmitter GABA (gamma-aminobutyric acid) by altering the expression of GABA-A receptor subunits. This makes it a critical tool for studying the biological foundations of anxiety and emotional regulation.

2. Influence on Enkephalin Degradation

Selank acts as an inhibitor of enkephalin-degrading enzymes. By slowing the breakdown of enkephalins (natural opioids in the brain), researchers can observe the peptide’s indirect effect on pain modulation and stress reduction.

3. Brain-Derived Neurotrophic Factor (BDNF)

Preliminary studies suggest that Selank may influence the expression of BDNF, a vital protein for the survival, growth, and maintenance of neurons. This has positioned Selank as a candidate for neuroprotective and cognitive enhancement research.

Primary Research Applications

Anxiolytic and Stress Response Studies

Scientists use Selank to study the reduction of fear and anxiety-like behaviors in animal models. Unlike many anxiolytics, Selank is studied for its “clean” profile, which appears to lack the risks of dependency or cognitive impairment in experimental settings.

Cognitive Function and Social Memory

Research protocols often employ Selank to investigate its impact on learning and memory. Its influence on the serotonergic and dopaminergic systems provides a broad landscape for studying how peptides can improve social recognition and cognitive flexibility.

Immunomodulation and Inflammation

Given its origin as a Tuftsin analogue, Selank is also studied for its effects on the immune system. Researchers investigate its ability to modulate cytokine levels (such as IL-6) and its potential role in managing neuroinflammation.

Storage, Reconstitution, and Stability

To ensure the integrity of the 10mg vial, laboratory professionals should adhere to the following handling procedures:

• Storage (Lyophilized): Store at -20°C for long-term stability. The peptide is stable at room temperature for approximately 3 weeks but should be refrigerated immediately upon arrival.

• Reconstitution: Use Sterile Water or Bacteriostatic Water.

• Handling: Do not shake the vial; gently swirl the liquid to ensure a clear solution.

• Post-Reconstitution: Store at 2°C to 8°C. It is recommended to use the reconstituted solution within 14 days for optimal results.

Why Source Our Selank 10mg?

In neurochemical research, even minor impurities can significantly alter behavioral data.

• Exceptional Purity: Verified by High-Performance Liquid Chromatography (HPLC) to ensure no degradation products are present.

• Stable Formula: Our PGP-modified sequence ensures the peptide remains active for longer during in vitro testing.

• Batch Transparency: Every shipment is backed by strict quality control standards to ensure reproducibility in your experiments.

Frequently Asked Questions (FAQ)

What is the difference between Selank and Semax?

While both are heptapeptides developed for neurological research, Selank is primarily studied for its anxiolytic (anti-anxiety) and immunomodulatory effects, whereas Semax is more frequently researched for its neurorestorative and nootropic (cognitive) properties.

Can Selank be used for sleep research?

While Selank is not a sedative, researchers often investigate its role in sleep cycles indirectly by studying its impact on the stress-induced pathways that typically disrupt normal circadian rhythms.