FOX04-DRI | 10mg

FOXO4-DRI 10mg — Advanced Senolytic Peptide for Cellular Rejuvenation and Longevity

FOXO4-DRI 10mg is a groundbreaking research peptide engineered to selectively eliminate senescent cells — commonly known as “zombie cells” — that accumulate in aging tissues and drive chronic inflammation. By targeting the FOXO4-p53 protein interaction responsible for keeping these damaged cells alive, FOXO4-DRI restores healthy cellular turnover, making it one of the most promising compounds in modern longevity and anti-aging research.

What Is FOXO4-DRI 10mg?

FOXO4-DRI is a D-retro-inverso (DRI) peptide — a modified version of a naturally occurring protein segment designed for increased stability and bioavailability. It works by disrupting the FOXO4-p53 interaction inside senescent cells. In healthy cells, p53 triggers apoptosis (programmed cell death) when damage is detected. In senescent cells, FOXO4 sequesters p53, blocking this process and allowing zombie cells to survive and secrete harmful inflammatory signals known as the Senescence-Associated Secretory Phenotype (SASP). FOXO4-DRI breaks this interaction, freeing p53 to initiate apoptosis exclusively in senescent cells — leaving healthy cells completely unharmed.

Key Benefits of FOXO4-DRI 10mg

1. Targeted Senescent Cell Clearance

FOXO4-DRI selectively induces apoptosis in senescent cells without affecting surrounding healthy tissue. Research indicates this targeted clearance can reverse several markers of physical aging, including reduced fitness levels, loss of fur density in animal models, and organ dysfunction associated with chemotherapy-induced senescence.

2. Anti-Aging and Longevity Support

By eliminating the source of chronic, low-grade inflammation associated with cellular aging (inflammaging), FOXO4-DRI may contribute to healthspan extension. Preclinical studies have demonstrated improved physical performance, restored renal function, and enhanced coat density in aged animal subjects following peptide administration — all hallmarks of biological rejuvenation.

3. Tissue Regeneration and Organ Health

Clearing senescent cells creates space for healthy progenitor cells to proliferate and replace damaged tissue. This process supports the regenerative capacity of organs including the liver, kidney, and muscle tissue— making FOXO4-DRI a compelling candidate in research addressing age-related organ decline and chemotherapy side effects.

4. Reduction of the SASP Inflammatory Cascade

The Senescence-Associated Secretory Phenotype (SASP) involves the secretion of pro-inflammatory cytokines, growth factors, and proteases that damage neighboring cells. FOXO4-DRI suppresses this cascade by eliminating the senescent cells that drive it, potentially reducing systemic inflammation linked to metabolic disorders, neurodegeneration, and cardiovascular disease.

Research Protocols and Dosage Guidelines

FOXO4-DRI is strictly a research compound. The following dosage ranges are based on preclinical data and researcher community protocols:

• Standard Research Dose: 1–5mg per kg of body weight (preclinical rodent studies)
• Administration Route: Subcutaneous or intraperitoneal injection (research use only)
• Reconstitution: Use bacteriostatic water for injection; store at 2–8°C after reconstitution
• Cycle Frequency: Intermittent dosing protocols — typically 3 consecutive days on, followed by a rest period
• Storage: Lyophilized powder stable at -20°C for up to 24 months

Product Specifications

• Peptide Name: FOXO4-DRI (D-Retro-Inverso FOXO4 Peptide)
• CAS Number: 1392278-76-0
• Molecular Formula: Custom D-amino acid sequence
• Vial Size: 10mg lyophilized powder
• Purity: ≥98% (HPLC verified)
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in bacteriostatic water or DMSO
• Intended Use: Research purposes only

Why Choose Our FOXO4-DRI 10mg?

Our FOXO4-DRI 10mg is produced using advanced solid-phase peptide synthesis (SPPS) technology with D-amino acid incorporation for maximum in vivo stability. Every batch undergoes independent third-party HPLC and mass spectrometry analysis to confirm identity, purity, and concentration — ensuring the reliability your research demands.

Quality and Purity You Can Rely On

• ≥98% purity confirmed by third-party HPLC testing
• Mass spectrometry verified for correct molecular identity
• Sterile-filtered and lyophilized under GMP-aligned conditions
• Tamper-evident sealed vials with full batch traceability
• Discreet, temperature-controlled packaging with worldwide shipping