Melanostatin DM 200mg | Premium Research-Grade Peptide

Comprehensive Product Overview: Melanostatin DM (200mg)

The Melanostatin DM 200mg (also known as Nonapeptide-1) is a high-potency, research-grade peptide designed for advanced biochemical analysis and laboratory investigations into pigment modulation. This compound acts as a selective antagonist to the Melanocortin-1 Receptor (MC1R), providing researchers with a precise tool to study the inhibition of tyrosinase activity and the subsequent regulation of melanin synthesis.

This 200mg lyophilized format is engineered for laboratories requiring high-throughput testing or longitudinal studies. By providing a substantial quantity in a single vial, researchers can maintain consistent concentration levels across multiple experimental stages, reducing the margin of error associated with batch-to-batch variability.

Technical Specifications and Biochemical Profile

Molecular Precision and Synthesis

Our Melanostatin DM is synthesized using advanced Solid Phase Peptide Synthesis (SPPS) technology, followed by multiple purification cycles to ensure a purity level of $\ge$ 99%. Each batch is verified via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure the sequence remains uncompromised.

• Amino Acid Sequence: Met-Pro-D-Phe-Arg-Trp-Phe-Lys-Pro-Val

• Molecular Formula: $C_{61}H_{87}N_{15}O_{9}S$

• Molecular Weight: Approximately $1206.5 \text{ g/mol}$

• Form: Sterile, Lyophilized Crystalline Powder

Stability and Storage Protocols

The 200mg vial of Melanostatin DM is vacuum-sealed to prevent oxidation and moisture ingress. To preserve the structural integrity of the peptide bonds, the following storage parameters are recommended:

• Lyophilized Powder: Stable at room temperature for short-term transit, but should be stored at -20°C for long-term preservation.

• Reconstituted Solution: Once mixed with Bacteriostatic Water or sterile saline, the solution must be refrigerated at 2°C to 8°C and utilized within 14 days to prevent degradation.

Research Applications and Laboratory Utility

MC1R Antagonism and Pigment Studies

Melanostatin DM is primarily utilized in research focused on the melanogenesis pathway. By competitively binding to the MC1R receptors on melanocytes, it prevents the action of the Alpha-Melanocyte Stimulating Hormone ($\alpha$-MSH). This makes it an essential compound for studies involving:

1. Hyperpigmentation Models: Analyzing the reduction of melanin overproduction in skin cell cultures.

2. Tyrosinase Inhibition: Studying the signaling pathways that trigger enzymatic browning and pigment formation.

3. Dermal Signaling: Investigating the communication between keratinocytes and melanocytes.

Advanced Analytical Advantage

The 200mg concentration is particularly beneficial for researchers conducting dose-response curves. Having a larger volume of the same lot number ensures that quantitative data—such as the $IC_{50}$ values for tyrosinase inhibition—remain highly accurate and reproducible across different trial groups.